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1994 2
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2003 2
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Page 1
Deregulation of the pRb-E2F4 axis alters epidermal homeostasis and favors tumor development.
Costa C, Santos M, Martínez-Fernández M, Lorz C, Lázaro S, Paramio JM. Costa C, et al. Oncotarget. 2016 Nov 15;7(46):75712-75728. doi: 10.18632/oncotarget.12362. Oncotarget. 2016. PMID: 27708231 Free PMC article.
E2F family members are divided into two groups: activators (E2F1-E2F3a) and repressors (E2F3b-E2F8). E2F4 accounts for a large part of the E2F activity and is a main E2F repressor member in vivo. ...However, the possible roles of E2F4 in this context are still to be …
E2F family members are divided into two groups: activators (E2F1-E2F3a) and repressors (E2F3b-E2F8). E2F4 accounts for a large part o …
CSE1L is a negative regulator of the RB-DREAM pathway in p53 wild-type NSCLC and can be targeted using an HDAC1/2 inhibitor.
Duan L, Tadi MJ, Maki CG. Duan L, et al. Sci Rep. 2023 Sep 27;13(1):16271. doi: 10.1038/s41598-023-43218-3. Sci Rep. 2023. PMID: 37759078 Free PMC article.
P53 represses transcription by activating p21 expression and promoting formation of RB1-E2F1 and RBL1/RBL2-DREAM transcription repressor complexes. The DREAM complex is composed of DP1, RB-family proteins RBL1 or RBL2 (p107/p130), E2F4/5, and MuvB. ...
P53 represses transcription by activating p21 expression and promoting formation of RB1-E2F1 and RBL1/RBL2-DREAM transcription repres …
E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor beta through E2F binding sites.
Li JM, Hu PP, Shen X, Yu Y, Wang XF. Li JM, et al. Proc Natl Acad Sci U S A. 1997 May 13;94(10):4948-53. doi: 10.1073/pnas.94.10.4948. Proc Natl Acad Sci U S A. 1997. PMID: 9144170 Free PMC article.
We show here that TGF-beta treatment of HaCaT cells induced the formation of E2F4-RB and E2F4-p107 complexes, which are capable of binding to E2F sites. ...Therefore, E2F functions to bring RB and p107 to E2F sites and represses gene expression by TGF-beta. These re …
We show here that TGF-beta treatment of HaCaT cells induced the formation of E2F4-RB and E2F4-p107 complexes, which are capabl …
E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control.
Gaubatz S, Lindeman GJ, Ishida S, Jakoi L, Nevins JR, Livingston DM, Rempel RE. Gaubatz S, et al. Mol Cell. 2000 Sep;6(3):729-35. doi: 10.1016/s1097-2765(00)00071-x. Mol Cell. 2000. PMID: 11030352 Free article.
Here, we report that simultaneous inactivation of E2F4 and E2F5 in mice results in neonatal lethality, suggesting that they perform overlapping functions during mouse development. ...However, they failed to arrest in G1 in response to p16INK4a. Thus, E2F4 and E2F5 a …
Here, we report that simultaneous inactivation of E2F4 and E2F5 in mice results in neonatal lethality, suggesting that they perform o …
E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression.
Chen CR, Kang Y, Siegel PM, Massagué J. Chen CR, et al. Cell. 2002 Jul 12;110(1):19-32. doi: 10.1016/s0092-8674(02)00801-2. Cell. 2002. PMID: 12150994 Free article.
We defined how, in the same context, Smad3 can also mediate transcriptional repression of the growth-promoting gene c-myc. A complex containing Smad3, the transcription factors E2F4/5 and DP1, and the corepressor p107 preexists in the cytoplasm. ...Previously known as the …
We defined how, in the same context, Smad3 can also mediate transcriptional repression of the growth-promoting gene c-myc. A complex contain …
Expression of cell cycle-regulated proteins pRB2/p130, p107, E2F4, p27, and pCNA in salivary gland tumors: prognostic and diagnostic implications.
Russo G, Zamparelli A, Howard CM, Minimo C, Bellan C, Carillo G, Califano L, Leoncini L, Giordano A, Claudio PP. Russo G, et al. Clin Cancer Res. 2005 May 1;11(9):3265-73. doi: 10.1158/1078-0432.CCR-04-2508. Clin Cancer Res. 2005. PMID: 15867222
This led us to investigate the role of pRb2/p130 in salivary tumors. We studied the expression of pRb2/p130, p107, E2F4, p27, and PcNA by immunohistochemistry in a panel of 44 salivary gland tumors. ...Interestingly, p107 nuclear expression showed a strong direct correlati …
This led us to investigate the role of pRb2/p130 in salivary tumors. We studied the expression of pRb2/p130, p107, E2F4, p27, and PcN …
Herpes simplex virus induces intracellular redistribution of E2F4 and accumulation of E2F pocket protein complexes.
Olgiate J, Ehmann GL, Vidyarthi S, Hilton MJ, Bachenheimer SL. Olgiate J, et al. Virology. 1999 Jun 5;258(2):257-70. doi: 10.1006/viro.1999.9755. Virology. 1999. PMID: 10366563 Free article.
Western blot analyses of whole cell extracts revealed that amounts of E2F4, E2F1, DP1, and p107 remained unchanged after infection of C33 cells. Analysis of cytoplasmic and nuclear fractions, however, revealed that cytoplasmic E2F4 decreased and nuclear E2F4 …
Western blot analyses of whole cell extracts revealed that amounts of E2F4, E2F1, DP1, and p107 remained unchanged after infection of …
Structural Conservation and E2F Binding Specificity within the Retinoblastoma Pocket Protein Family.
Liban TJ, Thwaites MJ, Dick FA, Rubin SM. Liban TJ, et al. J Mol Biol. 2016 Oct 9;428(20):3960-3971. doi: 10.1016/j.jmb.2016.08.017. Epub 2016 Aug 25. J Mol Biol. 2016. PMID: 27567532 Free PMC article.
In humans, Rb binds E2F1-E2F5, whereas p107 and p130 almost exclusively associate with E2F4 and E2F5. To identify the molecular determinants of this specificity, we compared the crystal structures of Rb and p107 pocket domains and identified several key residues that contr …
In humans, Rb binds E2F1-E2F5, whereas p107 and p130 almost exclusively associate with E2F4 and E2F5. To identify the molecular deter …
Characterization and functional analysis of SMAD2 regulation in hair follicle cycle in Angora rabbits.
Bao Z, Zhao B, Hu S, Yang N, Liu M, Li J, Liang S, Zhou T, Chen Y, Wu X. Bao Z, et al. Gene. 2021 Feb 20;770:145339. doi: 10.1016/j.gene.2020.145339. Epub 2020 Dec 22. Gene. 2021. PMID: 33333220
The knockdown and overexpression of SMAD2 could regulate HF growth and development related genes, such as WNT2, FGF2, and LEF1.Furthermore, SMAD2 may upregulate TGF-beta signaling pathway-related genes, including TFDP1, E2F4, and RBL1. In conclusion, our results ind …
The knockdown and overexpression of SMAD2 could regulate HF growth and development related genes, such as WNT2, FGF2, and LEF1.Furthermore, …
50 results